Soursop is used as an antispasmodic, emetic, and sudorific in herbal medicine. A decoction of the leaves is used to kill head lice and bed bugs while a tea from the leaves is well known in the West Indies to have sedative properties. The juice of the fruit is taken orally for hematuria, liver complaints, and urethritis. An extract of the stem bark of A. muricata has been shown to exhibit antistress activity. Studies have found that an ethanol extract of the stem bark of soursop induces a significant reduction in stress levels in stress-induced rats, suggesting a role for the extract as an adaptogenic agent. The plant extract was found to reduce the stress-induced rise in brain 5-hydroxytryptamine (5-HT) and 5-hydroxyindole acetic acid (5-HIAA) levels, by increasing the levels of the MAO enzyme, which was observed to have lowered 5-HT and 5-HIAA . Administration of the ethanol extract has also been demonstrated to significantly inhibit the cold immobilization stress-induced increase in lipid peroxidation in the liver and brain of rats .