Soursop (annona muricata l.): composition, nutritional value, medicinal uses, and toxicology
- BIOACTIVITY AND TOXICOLOGY Analysis of defatted seeds from ripe soursop led to the isolation of annonaceous acetogenins including annonacin, isoannonacin, isoannonain-10-one,
goniothalamicin, and gigantetrocin [135–137] which showed cytotoxicities for the A-549 lung carcinoma, MCF-7 breast carcinoma, and HT-29 colon adenocarcinoma human tumor cell lines [138–140]. These single ring acetogenins
are not considered as biologically potent as nonadjacent bistetrahydrofuran ring compounds . Bioactivity-directed fractionation
of the leaves of soursop led to the isolation of two additional acetogenins, muricoreacin
murihexocin, that also showed significant cytotoxicities in six human tumor cells, including
PACA-2 pancreatic carcinoma and PC-3 prostate adenocarcinoma cell lines .