Soursop (annona muricata l.): composition, nutritional value, medicinal uses, and toxicology

  1. BIOACTIVITY AND TOXICOLOGY Analysis of defatted seeds from ripe soursop led to the isolation of annonaceous acetogenins including annonacin, isoannonacin, isoannonain-10-one,

goniothalamicin, and gigantetrocin [135–137] which showed cytotoxicities for the A-549 lung carcinoma, MCF-7 breast carcinoma, and HT-29 colon adenocarcinoma human tumor cell lines [138–140]. These single ring acetogenins

are not considered as biologically potent as nonadjacent bistetrahydrofuran ring compounds [141]. Bioactivity-directed fractionation

of the leaves of soursop led to the isolation of two additional acetogenins, muricoreacin

and

murihexocin, that also showed significant cytotoxicities in six human tumor cells, including

PACA-2 pancreatic carcinoma and PC-3 prostate adenocarcinoma cell lines [142].

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07 October 2014

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