Antiproliferative effect of annona muricata linn. leaves on ehrlich ascites carcinoma

Cancer is a dreadful disease caused by abnormal and uncontrolled cell division. Lung cancer remains a major cause of cancer-related deaths in men and the second most common cancer in women, responsible for 1.59 million deaths worldwide annually. Treatment of cancer usually involves surgery, chemotherapy, and radiation therapy, or a combination of these. Despite these therapeutic options, cancer remains associated with high mortality. Traditional medicine which involves the use of herbs has been used to treat various types of cancer and this has been found to be effective with minimal or no side effects. Annona muricata L. also called “Soursop” or “Sharp Sharp” is traditionally used in treatment of cancer. There are many claims that Annona muricata L. can kill cancer, since its leaves, seeds and fruits contain active compound called annonaceous acetogenins

The present investigation was to screen Antiproliferative effect of Annona muricata Linn. on Ehrlich ascites carcinoma. As per OECD guideline 425, acute toxicity study of methanolic extract of Annona muricata Linn was performed and two doses 200 mg/kg and 400 mg/kg were selected for the study. Injected EAC cell for mice. Four groups (n=6) were selected. Group I served as normal Control, Group II served as EAC control, Group III served as EAC + 200mg/kg, Group IV served as EAC + 200mg/kg. On 90 days fasting blood sample were collected and analyzed for haematological parameters in EAC bearing mice. In Ehrlich ascites carcinoma model, the tumor bearing mice treated with methanol extract of Annona muricata leaves 200 mg/kg and 400 mg/kg once daily orally started 24 h after inoculation significantly reduced the viable cell count. The dose level of 400 mg/kg showed a significant increase in non-viable count with a significant decrease in body weight of animals compared to EAC control animals. a) Before treatment b)After treatment

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18 January 2017

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